Work

Heteroaryl-Directed Iridium-Catalyzed Enantioselective C–H Alkenylations of Secondary Alcohols

Year: 2024

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Under iridium-catalyzed conditions, 2-aza-aryl-substituted secondary alcohols undergo C(sp 3 )–H addition reactions to alkynes to provide alkenylated tertiary alcohols. The processes occur with very high regio- and enantioselectivity. An analogous addition to styrene is shown to provide a prototype C(sp 3 )–H alkylation process. A mechanism based on directed aza-enolization of the reactant alcohol is proposed.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.4c16414

Authors: Wenbin Mao, Craig M. Robertson, John F. Bower

Institution: University of Liverpool

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: University of Liverpool, Deutsche Forschungsgemeinschaft, H2020 European Research Council