Work

Photoexcited Hantzsch Ester Anions Enabled C−F Bond Activation and Hydro‐Difluoroalkylation of Arylethylenes Through Dual‐SET Process

Year: 2024

Type: article

Abstract: In this study, we reported a new approach to activate the C-F bond of trifluoromethylarenes to achieve the hydro-difluoroalkylation of arylethylenes using photoexcited Hantzsch esters (HEs) anions. A wide range of α,α-difluoroalkanes was synthesized. Late-stage functionalization of drug molecules and synthesis of bioactive molecule bioisostere were also presented. Mechanistic studies revealed that the dual-single electron transfer (SET) process of HEs anion was the key to this reaction.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202404116

Authors: Nan Li, Jia‐Le Si, Meng‐Yu Xu

Institution: Huaibei Normal University

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: bronze

Funders: National Science Foundation, National Natural Science Foundation of China, University of Science and Technology of China, Huaibei Normal University

Award: G6272689594