Iron Catalyzed Radical Alkylation of Cyclic Ketimines with Olefins via Metal Hydride Atom Transfer
Year: 2024
Type: article
Abstract: Here, we present an innovative approach to achieve Minisci‐type alkylation of cyclic N‐ketimines, enabling access to a diverse range of valuable alkylated sulfonyl ketimines via iron hydride hydrogen atom transfer. More than 35 examples are shown with a wide range of substrates. Additionally, this system is easy to operate and can be efficiently scaled up. Mechanistic investigations revealed that the alkyl radical process involved and the air acts as the sole oxidant in this system.
Source: Advanced Synthesis & Catalysis
Authors: Xixi Hu, Ruizhi Sun, Yu Tian, Xinyue Xu, Yijia Zhu, Hui Liu, Dong Liu, Lizhi Zhang
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Award: G2559473805
OpenAlex ID: W4405721279