Work

Ligand Assisted Co(II)‐Catalyzed Multicomponent Synthesis of Substituted Pyrroles and Pyridines

Year: 2024

Type: article

Abstract: Herein, we describe a sustainable Co(II)‐catalyzed synthesis of pyrroles and pyridines. Using a Co(II)‐catalyst [CoII2(La)2Cl2] (1 a) bearing redox‐active 2‐(phenyldiazenyl)‐1,10‐phenanthroline) (La) scaffold, various substituted pyrroles and pyridines were synthesized in good yields, taking alcohol as one of the primary feedstock. Pyrroles were synthesized by the equimolar reaction of 2‐amino and secondary alcohols. A series of 2,4,6‐substituted symmetrical pyridines were prepared via a three‐component reaction of NH4OAc with 1 : 2.2 molar primary and secondary alcohols, respectively. Unsymmetrically substituted 2,4,6‐trisubstituted, 2,4,5,6‐tetrasubstituted, and 2,3,4,5,6‐pentasubstituted pyridines were achieved via a multi‐component coupling reaction of alcohols and NH4OAc. Catalyst 1 a showed encouraging results during the gram‐scale synthesis of these N‐heterocycles. Mechanistic investigation revealed synergistic involvement of cobalt metal and the ligand during the catalytic reactions.

Source: Chemistry - An Asian Journal

DOI: 10.1002/asia.202401038

Authors: Subhajit Chakraborty, Arijit Singha Mohapatra, Subhangi Saha, Sutanuva Mandal, Nanda D. Paul

Institutions: Indian Institute of Engineering Science and Technology, Shibpur, Banwarilal Bhalotia College

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Ministry of Education, India

Award: G6222471256