Work

Targeting host integrated stress response: lead discovery of flavonoid compounds active against coronaviruses PEDV and PDCoV

Year: 2024

Type: article

Abstract: We have discovered a new class of flavonoid-based host integrated stress response (ISR) activators that exhibit potent antiviral activity against coronaviruses PEDV and PDCoV. They are host-directed antivirals (HDAs).

Source: RSC Medicinal Chemistry

DOI: 10.1039/d4md00846d

Authors: Liang Yi, Yishuai Wang, Jiehuang Wang, Yihan Chen, Weixue Huang, Ying Liao, Qingwen Zhang

Institutions: Shanghai Jiao Tong University, Shanghai Institute of Pharmaceutical Industry, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry

Language: English

Topic: Animal Virus Infections Studies

Subfield: Animal Science and Zoology

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: East China University of Science and Technology, Science and Technology Commission of Shanghai Municipality, Shanghai Key Laboratory of New Drug Design

Award: G175928511

OpenAlex ID: W4405726511

FWCI: 0.764

Cites: 34

Cited by: 3

Related to: 10