Clinical Impact of TP53 Mutations in Patients with Head and Neck Cancer Who Were Treated with Targeted Therapies or Immunotherapy
Year: 2024
Type: article
Abstract: PURPOSE: Tumor suppressor p53 (TP53) mutations are common in head and neck squamous cell carcinoma (HNSCC). We evaluated their clinical impact in patients treated with targeted agents or immunotherapy in the KCSG HN15-16 TRIUMPH trial. Materials and Methods: We analyzed clinical characteristics and outcomes of patients with TP53 mutations in the TRIUMPH trial, a multicenter, biomarker-driven umbrella trial in Korea. Patients were assigned to treatment groups based on genomic profiles: group 1, alpelisib; group 2, poziotinib; group 3, nintedanib; and group 4, abemaciclib. If there was no identifiable target, the patients were allocated to group 5 (durvalumab±tremelimumab). RESULTS: TP53 mutations were detected in 116/179 patients (64.8%), more frequently in human papillomavirus-negative and non-oropharyngeal cancers. Patients with TP53 mutations exhibited shorter progression-free survival than TP53 wild-type in all the patients (1.7 vs. 3.8 months, p=0.002) and in those who received targeted treatments (2.5 vs. 7.3 months, p=0.009). Furthermore, TP53 mutations were strongly associated with poor overall survival than TP53 wild-type in all the patients (11.1 vs. 28.8 months, p=0.005) and in group 5 (8.1 vs. 33.0 months, p=0.001). CONCLUSION: TP53 mutations were associated with aggressive clinical characteristics and poor survival, particularly in HNSCC patients treated with immunotherapy.
Source: Cancer Research and Treatment
DOI: 10.4143/crt.2024.836
Institutions: Korea University Guro Hospital, Yonsei University, Yonsei University Health System, Kangbuk Samsung Hospital, Sungkyunkwan University, Konyang University, Konyang University Hospital, Kosin University Gospel Hospital, Dongnam Institute of Radiological & Medical Sciences, Seoul National University, Seoul National University Bundang Hospital, Ajou University Hospital, Ajou University, Yeungnam University Medical Center, Yeungnam University College, Yeungnam University, Wonju Severance Christian Hospital, Chungnam National University, Chungnam National University Hospital, Chosun University Hospital, Asan Medical Center, University of Ulsan, Yonsei Cancer Hospital
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: G3307676988, G3621008138, G8985938981
OpenAlex ID: W4405727250