Incidence of acute ischemic stroke after COVID-19 or influenza among older adults, findings from PCORnet and HealthVerity, 2022
Year: 2024
Type: preprint
Study design: Observational Study
Abstract: Background Although COVID-19 is a known risk factor for thrombotic conditions including embolism, stroke, and myocardial infarction, stroke incidence after implementation of thromboprophylaxis during COVID-19 hospitalization in 2021 and how incidence may differ from influenza is unknown. Methods PCORnet and HealthVerity (HV) data assets were used to identify patients aged ≥65 years with no prior stroke and COVID-19 or influenza during January 1-December 31, 2022, and AIS from 3 days before to 28 days after COVID-19 or influenza diagnosis. Overall demographic information (age [for HV], sex, race/ethnicity), underlying conditions, level of care, outcomes, and incidence were described and compared between those with early (-3 to 7 days from diagnosis date) and late (8 to 28 days) AIS. Results Among 245,352 (PC) and 639,396 (HV) patients aged ≥65 years with COVID-19, the incidence of ischemic stroke in the 3 days prior to 7 days after diagnosis of COVID-19 (PC: 962/100,000 and HV: 447/100,000) and influenza (PC: 589/100,000 and HV: 387/100,000) was significantly higher than in the 8 to 28 days after diagnosis (COVID PC: 81/100,000 and HV: 141/100,000)(influenza PC:75/100,000 and HV: 15/100,000)(all P<0.01). Conclusions Continued risk for AIS with acute COVID-19 and influenza underscore the importance of monitoring and prevention measures for older adults.
Source: medRxiv
Authors: Emilia H. Koumans, Julia Raykin, Tegan K. Boehmer, Sharon Saydah, Jennifer Wiltz, Shikha Garg, Carol E. DeSantis, Thomas W. Carton, Lindsay G. Cowell, Deepika Thacker, Jonathan Arnold, Sonja A. Rasmussen, Samantha J. Smith, Kimberly Barrett, Christine Draper, Fátima Coronado, Elizabeth A. Lundeen, Rebecca C. Woodruff, Jason P. Block
Institutions: Centers for Disease Control and Prevention, Louisiana Public Health Institute, The University of Texas Southwestern Medical Center, Nemours Children's Health System, University of Pittsburgh, Johns Hopkins University, Johns Hopkins Medicine, Harvard Pilgrim Health Care, Harvard University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4405729708