Work

Dengue infection changes the expressions of CD154 and CD148 in human platelets

Year: 2024

Type: article

Abstract: • An increased expression of membrane-associated CD154 on platelets may enhance inflammation in dengue patients. • Reduced levels of membrane-associated CD148 on platelets were observed in dengue patients. • Strong correlation of CD148 with αIIbβ3 (CD41/CD61) was noted in dengue patients. Platelets are essential for hemostasis and vascular integrity. Platelets recognize dengue virus through the DC-SIGN receptor. Upon pathogen recognition, platelets rapidly modulate the expression of adhesion molecules to trigger immune cell interactions and regulate the immune response. In this study, we aimed to examine the expression levels of three molecules, CD151, CD154, and CD148 on platelets in dengue patients. A significantly increased expression of CD154 and reduced expression of CD148 was observed in dengue patients compared to healthy subjects ( p < 0.0001). Moreover, a strong positive correlation between CD148 and CD41/CD61 ( p < 0.0001) was noted in dengue patients. In summary, we demonstrated the altered expressions of CD154 and CD148 on platelets in dengue patients that may play a crucial role in dengue pathogenesis.

Source: Virus Research

DOI: 10.1016/j.virusres.2024.199519

Authors: Sayali Vedpathak, Sonali Palkar, AkhileshChandra Mishra, Vidya A Arankalle, Shubham Shrivastava

Institution: Bharati Vidyapeeth (Deemed to be University)

Language: English

Topic: Mosquito-borne diseases and control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,830