Predictive Ability of the Academic Research Consortium High Bleeding Risk Criteria in Patients Undergoing Percutaneous Coronary Intervention According to Body Mass Index
Year: 2024
Type: article
Study design: Observational Study
Abstract: ABSTRACT Background Whether the high bleeding risk (HBR) criteria of the Academic Research Consortium (ARC) have a consistent predictive ability across different categories of body mass index (BMI) remains unclear. Methods Consecutive patients undergoing percutaneous coronary intervention (PCI) between 2012 and 2019 at Mount Sinai Hospital (New York, USA) were stratified into five BMI categories (18.5–24.9 kg/m2 [normoweight], 25–29.9 kg/m2 [overweight], 30–34.9 kg/m2 [Class I obesity], 35–39.9 kg/m2 [Class II obesity], and BMI ≥ 40 kg/m2 [Class III obesity]) and by HBR status. The primary outcome was major bleeding at 1 year after PCI. Results Among 16,123 patients, normoweight, overweight, class I, class II, and class III obesity were found in 23.7%, 41%, 24.5%, 9.3%, 4.8% of patients, respectively. Fulfillment of the ARC‐HBR criteria ranged between 34.4% and 48.5% across these BMI categories. One‐year rates of major bleeding was 6% in normoweight patients (reference), 4.1% in overweight (adj.HR 0.73, 95% CI 0.60–0.88), 3.5% in class I (adj.HR 0.62, 95% CI 0.49–0.77), 4.2% in class II (adj.HR 0.72, 95% CI 0.54–0.96), and 4.9% in class III (adj.HR 0.83, 95% CI 0.58–1.18) obesity. Consistently across the 5 BMI categories, the fulfillment of ARC‐HBR criteria was related with > 4% rates of major bleeding at 1‐year and with ≥ 2 times risk increase of major bleeding (pint = 0.177). Conclusions The presence of the ARC‐HBR criteria predicted a significantly increased risk of major bleeding consistently in each BMI category.
DOI: 10.1002/ccd.31322
Institution: Icahn School of Medicine at Mount Sinai
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4405732460