Does cognitive intra-individual variability predict change in everyday functioning performance in women with and without HIV in the Women’s Interagency HIV Study?
Year: 2024
Type: article
Abstract: This study examined the association between cognitive intra-individual variability (IIV), a non-mean-based indicator of underlying neuropathology, and self-reported everyday functioning of 1,086 women with HIV (WWH) and 494 socio-demographically similar women without HIV (WWoH). Objective cognitive performance across seven domains and the self-rated Lawton & Brody scale of Instrumental Activities of Daily Living (IADL) were assessed among participants of the Women’s Interagency HIV Study. Two types of cognitive IIV were calculated by taking the standard deviation across seven cognitive domains to calculate dispersion: 1) intra-individual standard deviation (denoted as sdIIV) and 2) coefficient of variation (denoted as covIIV). To account for the longitudinal nature of the data, generalized linear mixed effect models were conducted to examine associations between the dispersion coefficient of cognitive IIV (predictor (sdIIV and covIV)) and functional outcomes (item level scores). Models were conducted in the overall sample (WWH + WWoH), WWH only, virally suppressed (VS)-WWH, and WWoH. sdIIV and covIIV were not associated with any of the IADL items among WWoH but were for WWH and VS-WWH. In WWH covIIV was predictive of poorer functional performance on twice as many IADL items (10 items—money and bills, buying groceries, getting where you need to go, using the phone, home repairs, dressing, laundry, taking/keeping track of medications, taking care of children, work) than sdIIV (5 items). In this study, cognitive IIV predicts functional impairment and different calculations of IIV produce differential predictive value, especially for WWH.
Source: Applied Neuropsychology Adult
Authors: David E. Vance, Yanxun Xu, Raha Dastgheyb, Pauline M. Maki, Jiayue Zhang, Gayle Springer, Kathryn Anastos, Deborah R. Gustafson, Kathleen M. Weber, Derek M. Dykxhoorn, Joel Milam, Monica M. Diaz, Seble G. Kassaye, Drenna Waldrop, Junghee Lee, Mirjam‑Colette Kempf, Deborah Konkle‑Parker, Karl Goodkin, Andrew J. Leviner, Matthew Wright, Deborah Jones, Leah. H. Rubin
Institutions: University of Alabama at Birmingham, Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, University of Illinois Chicago, Albert Einstein College of Medicine, Montefiore Medical Center, SUNY Downstate Health Sciences University, Hektoen Institute, University of Miami, Dr. John T. Macdonald Foundation, University of California, Irvine, University of North Carolina at Chapel Hill, Georgetown University, Emory University, University of Mississippi Medical Center, AIDS Clinical Trials Group, University of California, Los Angeles
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: G1400602301, Translational Biomedical Science Training Grant, G1655989834, G1773452051, G192128497, G248584506, G2755707676, G2759654445, G2839061624, G30074556, G319781266, G3242306066, G3418878615, G343705321, G483408255, G5431849782, G5747858550, University of Miami Developmental HIV/AIDS Mental Health Research Center (D-ARC), G693265041, Johns Hopkins Institute for Clinical and Translational Research, University of Pittsburgh MACS/WIHS CCS, MACS/WIHS -CCS, Emory Specialized Center of Research Excellence (SCORE) on Sex Differences, UNC MACS/WIHS Combined Cohort Study Clinical Research Site, Surviving the HIV Epidemic (S/HE) in metropolitan Washington DC - Advancing knowledge through cohort studies, Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study, MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS), Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center, UAB-MISS MACS/WIHS Combined Cohort Study, The University of Miami AIDS Research Center on Mental Health and HIV/AIDS - Center for HIV & Research in Mental Health (CHARM), UCLA Clinical and Translational Science Institute, Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS), UAB Center for AIDS Research (CFAR)
OpenAlex ID: W4405734199