The incidence of M. tuberculosis resistance to linezolid and bedaquiline in patients for the period 2011-2022
Year: 2024
Type: article
Study design: Observational Study
Abstract: The objective. To analyze the incidence of linezolid- and bedaquiline-resistant strains of M. tuberculosis from smear-positive TB patients in 2011–2022. Subjects and Methods. A total of 3637 clinical strains were obtained from patients undergoing treatment in the CTRI in 2011-2022. Drug susceptibility for linezolid and bedaquiline were determined using Bactec MGIT 960 (Becton Dickinson, USA) with a critical concentration of 1 mg/L. Results. 101 patients with linezolid- and bedaquiline-resistant strains were detected. The incidence of linezolid-resistance increases from 0,2% in 2011 to 5,5% in 2022 (p<0,05). The incidence of bedaquiline-resistance also increases from 1,4% in 2018 to 12,2% in 2022 (p<0,05). Conclusion. Resistance to linezolid and bedaquiline is increasing for the period 2011-2022. Molecular methods for linezolid and bedaquiline resistance detection are urgently needed.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4405737287