Work

The calcium channel blocker nimodipine inhibits spinal reflex pathways in humans

Year: 2024

Type: article

Abstract: The calcium channel antagonist nimodipine significantly reduces the size of the soleus H reflex and stretch reflex in healthy individuals without affecting maximum direct motor response (M max ) or the stretch reflex during voluntary activation. This underscores the importance of exploring nimodipine as a potential antispastic medication in the future.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00585.2024

Authors: Eva Rudjord Therkildsen, Jens Bo Nielsen, Jakob Lorentzen

Institutions: University of Copenhagen, Elsass Foundation, Rigshospitalet

Language: English

Topic: Botulinum Toxin and Related Neurological Disorders

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Novo Nordisk Foundation Center for Protein Research, University of Copenhagen