Gigantic retroperitoneal pararenal ancient schwannoma masquerading as a mesenchymal malignancy: A diagnostic conundrum
Year: 2024
Type: article
Study design: Case Report
Abstract: Ancient schwannoma is a rare benign variant of schwannoma with marked degenerative changes, often mimicking malignancies, particularly when retroperitoneal and pararenal. A 34-year-old woman presented with a rapidly growing 15 cm retroperitoneal pararenal mass. Imaging suggested an aggressive malignancy. Surgical resection and histopathology revealed a well-encapsulated tumor with degenerative changes, nuclear atypia, and strong S100 positivity, confirming ancient schwannoma. Complete excision achieved negative margins, and follow-up showed no recurrence. Diagnostic challenges arise from its rarity and atypical features. Histopathology is crucial for differentiation from malignancies. Ancient schwannomas should be considered for large retroperitoneal masses to ensure accurate diagnosis and management. • Rare Presentation and Diagnostic Challenge : A gigantic pararenal retroperitoneal ancient schwannoma mimicking a malignant mesenchymal tumor due to its size, location, and degenerative changes. • Key Role of Histopathology and IHC : Definitive diagnosis achieved through histopathological evaluation and immunohistochemical markers, particularly S100 positivity and a low Ki-67 index. • Clinical Relevance : Emphasizes the need to consider ancient schwannoma in the differential for large retroperitoneal masses and highlights surgical excision as curative with excellent prognosis.
Source: Urology Case Reports
Authors: Neha Aggarwal, Shaivy Malik, Charanjeet Ahluwalia
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,060
OpenAlex ID: W4405740056