Work

The role of BDNF in the antidepressant effects of electroconvulsive therapy

Year: 2024

Type: article

Abstract: Electroconvulsive therapy (ECT) is an effective treatment method for depression therapy. It produces a number of biological effects, including neurotrophic factors regulation. In the present paper, we investigated the ECT response in depressed rats subjected to the variable frequency ultrasound (20–45 kHz) and examined the contribution of brain-derived neurotrophic factor (BDNF) expression changes to the observed effects. The obtained results reflect the therapeutic potential of ECT for the treatment of depressive-like state in rodents and indicate the role of BDNF in these processes. In the future research, it is necessary to investigate the relationship between neurotrophin and structural changes and to study other neurotrophic biomarkers that may be associated with the development of depression-like state and the therapy response.

Source: Доклады Российской академии наук Науки о жизни

DOI: 10.31857/s2686738924060069

Authors: V. M. Ushakova, E. A. Zubkov, A. Y. Morozova, K. A. Pavlov, Y. A. Zorkina, O. V. Abramova, A. G. Ochneva, O. I. Gurina, K. S. Tarkovskaya, A. N. Inozemtsev, V. P. Chekhonin

Institutions: Lomonosov Moscow State University, Federal Medical Research Centre for Psychiatry and Narcology, Pirogov Russian National Research Medical University

Language: English

Topic: Electroconvulsive Therapy Studies

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4405745688

FWCI:

Cites: 11

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Related to: 10