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A Case of Rapid Transformation of a Nail Matrix Nevi to Melanoma After Messenger RNA COVID-19 Vaccine: A Cause or a Coincidence?

Year: 2024

Type: article

Abstract: Subungual melanoma is a variant of acral lentiginous melanoma that arises from the nail matrix. Subungual melanomas present unique clinical challenges due to diagnostic difficulties and the lack of a standardized protocol for surveillance, also, there are no evidence-based studies that determine the ideal frequency and duration of clinical and dermoscopy follow-ups in patients with longitudinal melanonychia. This is highlighted by a case of longitudinal melanonychia in a 53-year-old patient who underwent malignant transformation to subungual melanoma after a biphasic growth. Another problem raised is how long to observe longitudinal melanonychia, with the conclusion that it should be observed for lifetime. Finally, this report also illustrates the possible role of the COVID-19 messenger RNA vaccine in cancer development and/or progression.

Source: Cureus

DOI: 10.7759/cureus.76312

Authors: Maria Farhat, Joseph Zouein, Jad Abou Khater, Anne-Sophie Sarkis, Josiane Helou

Institutions: Université Libre de Bruxelles, Saint Joseph University, Erasmus Hospital, Duke Medical Center, Hôtel-Dieu de France

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405757748