Work

Directed stochasticity: Building biomolecular condensates in the right place

Year: 2024

Type: article

Abstract: Controlling biomolecular condensate formation within the nucleus is critical for genome function. In this issue, Xu et al. (https://doi.org/10.1083/jcb.202401036) report that KPNA3 promotes histone locus body formation and expression of replication-dependent histone genes by both importing NPAT into the nucleus and preventing NPAT condensation from improperly occurring in the cytoplasm.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.202412035

Authors: Mark S. Geisler, James P. Kemp, Robert J. Duronio

Institutions: University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center

Language: English

Topic: Nuclear Structure and Function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institute of General Medical Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G5552350555, Histone mRNA Regulation in Development, Epigenetic Control of the Cell Cycle During Animal Development