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A comprehensive characterization biotransformation of chlorinated paraffin by human and carp liver microsomes via liquid chromatography-high-resolution mass spectrometry and screening algorithm

Year: 2024

Type: article

Abstract: ) of CP-4 was higher in humans than in carp, indicating species-specific differences in its metabolism. This study also highlighted potential toxicity concerns, with computational predictions showing varying degrees of acute oral toxicity for CP-4 and its metabolites. These findings indicate significant species-specific differences in the biotransformation of CP-4, emphasizing the potential health and environmental risks associated with chlorinated paraffins and their metabolites, and underscore the need for further research to address these concerns.

Source: Environment International

DOI: 10.1016/j.envint.2024.109235

Authors: Liujun Chen, Caiming Tang, Zhiqiang Yu, Yanhong Zeng, Bixian Mai, Xiaojun Luo