Work

Physiological, biochemical, and genome-wide expression patterns during graded normobaric hypoxia in healthy individuals

Year: 2024

Type: article

Abstract: Our study delves into the multifaceted response to hypoxia, integrating gene expression and hematological, biochemical, and physiological assessments. Hypoxia, crucial in both physiology and pathology, prompts varied responses, necessitating a thorough systemic understanding. Examining healthy subjects exposed to graded normobaric hypoxia, we observed significant shifts in heart rate, oxygen saturation, and heart rate variability. Moreover, genomic analysis unveiled distinct gene signatures associated with physiological parameters, offering insights into molecular perturbations and adaptations to oxygen deprivation.

Source: Physiological Genomics

DOI: 10.1152/physiolgenomics.00056.2024

Authors: Ritu Rani, Rintu Kutum, Deep Shikha Punera, Anand Prakash Yadav, Vishal Bansal, Bhavana Prasher

Institutions: Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Academy of Scientific and Innovative Research, University of Delhi

Language: English

Topic: High Altitude and Hypoxia

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Ministry of AYUSH, Government of India