Hydrogen sulfide-mediated inhibition of ROCK 2 exerts a vasoprotective effect on ischemic brain injury
Year: 2024
Type: article
Abstract: This study employs a diverse array of methods; our collective findings indicate that H 2 S safeguards against ischemic brain injury by inhibiting ROCK activity, thereby promoting relaxation of cerebral smooth muscle and mitigating the impairment of cerebral smooth muscle cell function caused by oxygen-glucose deprivation/reoxygenation. In addition, our data underscore the critical role of ROCK 2 in mediating the cerebral protective effects of H 2 S, surpassing that of ROCK 1 .
Language: English
Topic: Sulfur Compounds in Biology
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4405763893