Common Variable Immunodeficiency with Isolated Gastrointestinal Symptom
Year: 2024
Type: article
Study design: Case Report
Abstract: Common variable immune deficiency (CVID) with the frequency of 1 in 25000 is the “COMMON” form among the primary immunodeficiency diseases. It has a phenotype encompassing symptoms involving the lungs, gastrointestinal (GI) tract often, and joints. Symptoms are due to autoimmune and inflammatory reactions. These are seen from childhood to adult life with variable progression. Diagnostic criteria are defined now and include ruling out acquired hypogammaglobulinemia and agammaglobulinemia and include genetic testing. A higher incidence of cancer of the lymphoid or GI tract is reported. Treatment is the replacement of immunoglobulins. We report a patient with CVID with isolated GI symptoms. CVID is a less suspected, less recognized disease in India. Isolated GI symptoms in the form of diarrhea with no sinopulmonary and other organ involvement are even more, less common.
Authors: Loganathan Goundappa, Anna Pulimood, Arun George, Leena Sree, Shivashankari Ramamurthy
Institution: Christian Medical College, Vellore
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4405766174