Work

Durable Complete Remission of Metastatic Gastric Cancer Following Platinum-Based Chemotherapy: A Case Report

Year: 2024

Type: article

Abstract: Gastric cancer is a common type of gastrointestinal tract malignancy. It is characterized by a poor prognosis - median survival for metastatic disease is about 12 months. A small percentage of gastric cancer is characterized by high sensitivity to systemic treatment, resulting in deep and durable responses. Predictors for such hyper-responses are still under investigation, and a wide variety of possible mechanisms exist, including the DNA damage response, intracellular signaling, immune engagement, genetic alterations, and the tumor microenvironment. Here we present a case of a 59-year-old patient with human epidermal growth factor receptor-2 (HER-2)-negative, programmed death ligand-1 (PD-L1) negative, mismatch repair proficient (pMMR) metastatic gastric cancer who reached a particularly long progression-free survival (PFS) exceeding 93 months.

Source: Cureus

DOI: 10.7759/cureus.76378

Authors: Weronika Pilch, Wiktoria Wojturska, Pawel M Potocki

Institution: Jagiellonian University

Language: English

Topic: Gastric Cancer Management and Outcomes

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Uniwersytet Jagielloński Collegium Medicum