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Diffuse Large B-cell Lymphoma with a Multilobated Nuclear Morphology Harboring t(14;18)(q32;q21) and t(3;22)(q27;q11)

Year: 2024

Type: article

Abstract: A 70-year-old woman was admitted to our hospital with dyspnea. Atypical cells with multilobated nuclei were observed in the pleural effusion. Diffuse large B-cell lymphoma (DLBCL) was diagnosed based on a cell block analysis. A chromosomal analysis of lymphoma cells revealed t(14;18)(q32;q21) and t(3;22)(q27;q11). The patient's disease was refractory to chemotherapy, and she died within one year. Although flower-like nuclei are typical of adult T-cell lymphoma/leukemia, similar multilobated nuclei may occur in DLBCL. Although multilobated DCBCL have been reported to have a better prognosis than other forms of DLBCL, the abovementioned translocations may have contributed to the patient's aggressive clinical course.

Source: Internal Medicine

DOI: 10.2169/internalmedicine.4719-24

Authors: Masahiro Manabe, Naoyuki Inano, Yuuji Hagiwara, Ki-Ryang Koh

Institution: Osaka General Hospital Of West Japan Railway Company (Japan)

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405780520

FWCI: 0.532

Cites: 19

Cited by: 2

Related to: 10