Structures of Polyacetoxybriaranes Extracted from the Sea Whip Octocoral Junceella fragilis
Year: 2024
Type: article
Abstract: In the present study, an algae-containing octocoral, Junceella fragilis, was subjected to chemical screening. The analysis resulted in the extraction of six polyacetoxybriaranes: a new compound, identified as fragilide Z (1), alongside previously identified analogs, which included 12-epi-fragilide G (2), fragilide P (3), junceellolide D (4), junceellonoid A (5), and juncin ZI (6). The structures of compounds 2-6 were investigated through single-crystal X-ray diffraction analysis, whereas that of 1 was examined through two-dimensional nuclear magnetic resonance analysis. Compounds 1-6 proved active in enhancing the growth of MG-63 human mesenchymal stem cells.
Authors: Hai Nhat Do, Chih-Yin Huang, Su-Ying Chien, Li-Guo Zheng, You-Ying Chen, Yun-Ting Zeng, Jui-Hsin Su, Zhi-Hong Wen, Yu-Chia Chang, Ping-Jyun Sung
Institutions: National Sun Yat-sen University, National Museum of Marine Biology and Aquarium, Zuoying Armed Forces General Hospital, Kaohsiung Armed Forces General Hospital, National Taiwan University, Chang Gung University of Science and Technology, Fu Jen Catholic University, Kaohsiung Medical University, China Medical University Hospital, China Medical University
Language: English
Subfield: Biotechnology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4405780526