Work

Improvement and Retention of Insulin Secretion in Slowly Progressive Type 1 Diabetes Mellitus by Diet Therapy and Exercise for Five Years

Year: 2024

Type: article

Abstract: There are no clear strategies for non-insulin-dependent slowly progressive type 1 diabetes mellitus (SPIDDM). We herein report a 25-year-old man with SPIDDM in whom appropriate diet therapy and exercise improved the initial insulin secretion without medication. After 12 months, his body weight decreased by 5.4 kg, and his muscle mass increased from 0.77 to 0.81 kg/body weight. Glycated hemoglobin levels were reduced from 6.4% to 5.7%. HOMA-IR decreased from 1.70 to 0.77; in particular, the insulinogenic index improved from 0.04 to 0.13. These improvements were maintained over five years with continuous lifestyle interventions. Patients with non-insulin-dependent SPIDDM may recover and retain their insulin secretion through lifestyle interventions.

Source: Internal Medicine

DOI: 10.2169/internalmedicine.4648-24

Authors: Toshihiro Sato, Tetsuro Tsujimoto, Michi Kobayashi, Hiroshi Kajio

Institutions: Tohoku University, National Center for Global Health and Medicine, Toranomon Hospital Kajigaya

Language: English

Topic: Diabetes Management and Research

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Center for Global Health and Medicine, Tohoku Medical and Pharmaceutical University