Fusion of polymer-coated liposomes and centrifugally spun microfibers as hybrid materials to enhance sustained release
Year: 2024
Type: article
Abstract: , under ultrasonication. We hypothesize that the fusion is driven by hydrophobic interactions between the liposomes and the fibers, which merge the materials through the lipid bilayer. The fused hybrid material solved the burst release problem observed when adhering plain liposomes to nanofibers. Both PEG and chitosan yielded a sustained release, where the release rate with the former was faster. These results demonstrate that the fusion of polymer-coated liposomes and microfibers enables more effective blending of the loaded carriers into the polymer microfibers. Ultimately, the fused liposome/microfiber hybrids are stable matrices and enhance the sustained release of molecular cargo.
Source: Nanoscale Advances
DOI: 10.1039/d4na00835a
Institution: Tecnológico de Monterrey
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,962
OpenAlex ID: W4405793169