Work

Triptophenolide Improves Rheumatoid Arthritis and Progression by Inducing Macrophage Toxicity

Year: 2024

Type: article

Abstract: To investigate the role and mechanism of triptophenolide (TRI) in resisting rheumatoid arthritis (RA). Network pharmacology analysis results suggested that TRI was related to multiple inflammation-related signaling proteins, and possessed the stable structural configuration. In animal experiments, TRI suppressed RA in mice, inhibited tissue inflammation, and improved synovial injury. Moreover, TRI can suppress RA via multiple signaling pathways, and inhibiting pyroptosis is one of the feasible treatments for improving RA.

Source: Journal of Biochemical and Molecular Toxicology

DOI: 10.1002/jbt.70096

Authors: Xiuxiu Pu, Qiao Ye

Institutions: Zhejiang Chinese Medical University, Jiaxing University

Language: English

Topic: Natural Compounds in Disease Treatment

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4405800025

FWCI: 3.337

Cites: 33

Cited by: 8

Related to: 10