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Bcl6 controls the stability and suppressive function of regulatory T cells in head and neck squamous cell carcinoma

Year: 2024
Type: article
Abstract: Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most common cancer globally. Most studies in HNSCC demonstrated that regulatory T (Treg) cells confine the anti-tumor activity of effector T cells which may contribute to the immune escape and uncontrolled tumor progression. Here, we uncovered that the specific abrogation of Bcl6 in Treg cells resulted in significantly delayed malignant transformation of 4NQO-induced tumorigenesis. Bcl6 deficiency impairs the lineage stability of Treg cells by down-regulating the histone H3K4 trimethylation. Importantly, Bcl6 inhibition repressed the tumor growth of murine HNSCC and exhibited synergistic effects with immune checkpoint blockade therapy. These findings suggest that Bcl6 can be exploited as a promising therapeutic target for HNSCC treatment.
DOI: 10.1016/j.gendis.2024.101505
Authors: Shuqiong Wen, Xingxing Su, Junyi Guo, Zhanpeng Ou, Lisha Wang, Zhengliang Yue, Jing Zhao, Ling Ran, Jianjun Hu, Yuzhu Wang, Mengqu Ran, Qinyi He, Ping Ji, Lilin Ye, Zhiyu Chen, Lifan Xu, Qizhao Huang
Institutions: Sun Yat-sen University, Stomatological Hospital of Chongqing Medical University, Army Medical University, Southwest Hospital, Central South University, Third Xiangya Hospital, Chongqing Medical University
Language: English
Subfield: Immunology
Open Access status: gold
Estimated APC paid: $2,500
Funders: National Science Foundation, National Natural Science Foundation of China, Natural Science Foundation of Chongqing, Southwest Hospital, Centre Scientifique et Technique du Bâtiment, National Science Fund for Distinguished Young Scholars
Awards: G2504271756, G2555378283, G2624095571, G2796437284, G3781747553, G4427435602, G504305494, G5712551088, G6345545436, G8886881878, G952981226
OpenAlex ID: W4405802507
FWCI: 0.278
Cites: 46
Cited by: 2
Related to: 10