Effect of an intensive lifestyle intervention on cystatin C–based kidney function in adults with overweight and obesity: From the PREDIMED‐Plus trial
Year: 2024
Type: article
Abstract: BACKGROUND: Large-scale trials evaluating a multicomponent lifestyle intervention aimed at weight loss on kidney function are lacking. METHODS: This was a post hoc analysis of the "PREvención con DIeta MEDiterránea-Plus" (PREDIMED-Plus) randomized controlled trial, including patients with overweight/obesity and metabolic syndrome, measured cystatin C and creatinine. Participants were randomly assigned (1:1) to an intensive weight loss lifestyle intervention (intervention group [IG]) consisting of an energy-restricted Mediterranean diet (MedDiet), physical activity promotion and behavioral support, or a control group (CG) receiving ad libitum MedDiet recommendations. The primary outcome was between-group differences in cystatin C-based kidney function (cystatin C-based estimated glomerular filtration rate-eGFRcys-and combined cystatin C-creatinine-based eGFR-eGFRcr-cys) change from baseline to 12 and 36 months. Secondary outcomes included between-group differences in creatinine-based eGFR (eGFRcr) and urinary albumin-to-creatinine ratio (UACR) change and the predictive capacity of these formulas at baseline for new-onset chronic kidney disease (CKD). RESULTS: [95% confidence interval -2.92 to -0.63], -1.37 [-2.22 to -0.53], and -0.91 [-1.74 to -0.71], respectively. At 36 months, the decline in eGFRcr-cys and eGFRcr was greater in the CG. No between-group differences in UACR were found. Significant adjusted areas under the curve for baseline eGFRcys and eGFRcr-cys were observed for incident CKD at 36 months, which were similar to those for eGFRcr and UACR. CONCLUSIONS: In older adults with overweight/obesity and metabolic syndrome, the PREDIMED-Plus intervention may be an optimal approach to preserve kidney function.
Source: Journal of Internal Medicine
DOI: 10.1111/joim.20038
Institutions: Instituto de Salud Carlos III, Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Centro de Investigación Biomédica en Red, Andalusian Centre for Nanomedicine and Biotechnology, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga, Universidad de Málaga, Institut de Recerca Biomèdica Catalunya Sud, Universitat Rovira i Virgili, Health Research Institute of the Balearic Islands, Research Institute of Health Sciences, Universitat de les Illes Balears, Navarre Institute of Health Research, Universidad de Navarra, Harvard University, Madrid Institute for Advanced Studies, IMDEA Food, Municipal Institute for Medical Research, Hospital del Mar Research Institute
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,550
Awards: G103709314, G1113503999, G1117758273, G1454612176, G1454926127, G1467763451, G1523448718, G1979843757, G1995910868, PREDIMED+DM: Efecto de una pérdida de peso con dieta mediterránea hipocalórica y promoción de la actividad física en la prevención de diabetes tipo 2 en personas con síndrome metabólico., G2099522283, G2112806441, G2797520734, G2998898069, G3112360373, G3113956371, PREDIMED+DM: Efecto de una pérdida de peso con dieta mediterránea hipocalórica y promoción de la actividad física en la prevención de diabetes tipo 2 en personas con síndrome metabólico., G3244812904, G3261168694, G3845464644, G4019470342, G4146373456, G4249122574, G4489413705, G4497211085, G4547114284, G4647567350, PREDIMED+DM: Efecto de una pérdida de peso con dieta mediterránea hipocalórica y promoción de la actividad física en la prevención de diabetes tipo 2 en personas con síndrome metabólico., G4706226233, G5020993016, G507383055, G5085273872, G5300178539, G5338013552, G5483964703, G5978131061, G603262213, G6127890710, G6353703441, G6386773067, G6491641282, G6665802792, G6722443107, G6730108257, G6744420142, G6768395742, G6801418685, G685580432, G6902587947, G7070804947, G7162709665, G7216001737, G7327544411, G7373540289, G7376663786, G7538835637, G7761133213, G787942307, G792791549, G8032860944, G8171233546, G831563074, G833365288, G8379718705, PREDIMED+DM: Efecto de una pérdida de peso con dieta mediterránea hipocalórica y promoción de la actividad física en la prevención de diabetes tipo 2 en personas con síndrome metabólico., G8510585312, G8554236099, G8722415115, G8743244469, G8796694320, G8847519530, G8979101691, G9000212679
OpenAlex ID: W4405807254