Work

Staying sane in the membrane: Neutral sphingomyelinase 2 as a master regulator of plasma membrane ceramide

Year: 2024

Type: article

Abstract: Ceramide, a key signaling sphingolipid in the plasma membrane, plays a pivotal role in fundamental cellular processes such as adhesion, polarity, and programmed cell death. The generation of plasma membrane ceramide is largely attributed to the activity of two types of sphingomyelinases: neutral sphingomyelinase 2 (nSMase2, Smpd3) and acid sphingomyelinase (aSMase, Smpd1). While many studies have explored ceramide generation following experimental activation of these enzymes, the mechanisms governing basal or steady-state ceramide levels have remained poorly understood.

Source: Journal of Lipid Research

DOI: 10.1016/j.jlr.2024.100737

Authors: Zainuddin Quadri, Erhard Bieberich

Institution: University of Kentucky

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,800

Funders: National Institutes of Health, National Institute on Aging