Role and Application of Wnt/β-catenin Signaling Pathway in Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
Year: 2024
Type: article
Abstract: The Wnt/β-catenin signaling pathway is a crucial signaling mechanism in multicellular organisms, regulating a variety of cellular behaviors. It acts a significant role in the differentiation of bone marrow mesenchymal stem cells (MSCs) into osteoblasts and in maintaining bone homeostasis. This involves promoting gene expression that is relevant and interacting with other pathways to boost osteogenic differentiation when inhibiting the differentiation of cartilage and adipocytes. This paper reviews the role of the MSCs' osteogenic differentiation and the Wnt/β-catenin signaling pathway, explores the relationship between abnormalities in this pathway and various skeletal diseases, and discusses The Wnt signaling pathway can potentially be targeted in order to create medicinal strategies for these conditions, offering new insights for the treatment of skeletal disorders.
DOI: 10.54097/ddt58253
Authors: Linlang Xu, Ziheng Zeng
Institution: South China Agricultural University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4405809117