Year: 2024
Type: article
Abstract: This study investigates a sequential clinical trial comparing two treatments with dichotomous outcomes. We evaluate the effectiveness of five adaptive procedures and three randomization methods for assigning patients to different therapies. The primary objective is to identify an optimal treatment allocation policy that maximizes the proportion of successful outcomes in a trial. By comparing the performance of adaptive and randomized procedures, this research provides valuable insights for enhancing treatment allocation strategies in clinical trials, ultimately aiming to improve the overall success rates of therapeutic interventions.
Source: Mathematics
DOI: 10.3390/math13010044
Authors: Chien-Tai Lin, Yun-Wei Li, Yi-Jun Hong
Institutions: Tamkang University, National Yang Ming Chiao Tung University
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,955
OpenAlex ID: W4405809825