Work

Programmable DNA Hydrogels with Zinc Oxide Nanoparticles and Cisplatin for Diagnosis and Treatment of Oral Squamous Cell Carcinoma

Year: 2024

Type: article

Abstract: This study explores the potential of DNA hydrogels as a novel approach for diagnosing and treating Oral Squamous Cell Carcinoma (OSCC). In the experiment, DNA hydrogels are synthesized and loaded with Zinc Oxide Nanoparticles (ZnO NPs) and Cisplatin. In vitro experiments evaluated drug delivery efficacy and the effect on cancer cell viability. In vivo, studies used mice models to assess the therapeutic potential and antimicrobial activity of the DNA hydrogels. Results demonstrate that DNA hydrogels significantly improve the delivery of Cisplatin to cancer cells, potentially allowing for lower drug doses and reduced side effects. The combination of Cisplatin and ZnO NPs show the most potent antibacterial effect against bacterial strains associated with OSCC. Analysis indicates that ZnO NPs within the hydrogels improve the efficacy of contrast agents, facilitating earlier and more accurate tumor diagnosis. The findings highlight that DNA hydrogels loaded with therapeutic agents can enhance drug delivery and reduce side effects, while ZnO NPs improve tumor diagnosis. DNA hydrogels may represent a promising patient-centric approach for more effective OSCC treatment.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.202402895

Authors: Dan Zhao, Lin Liu, Gang Ping Wang, Xi Cheng

Institutions: Southwest Medical University, Affiliated Hospital of Southwest Medical University, Hohai University, Zhejiang University Medical College Affiliated Stomatological Hospital, Zhejiang University

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Southwest Medical University