Year: 2024
Type: article
Abstract: Three fungal strains were employed for stereoselective oxidation of the cheap and commercially available substrate 2-phenylethanol, what resulted in chiral building blocks receiving. Whole-cells biocatalysts were as follows: Beauveria bassiana DSM 1344, Beauveria brongniartii DSM 6651 and Rhizopus arrhizus DSM 1185. The main product of Beauveria bassiana bioconversion, was 1-phenylethane-1,2-diol obtained, depending on the form of the biocatalyst, as a R-enantiomer (e.g. 99.9%), with fresh biomass application or as racemic mixture in case of immobilization in agar- agar. The very best and pioneer results for the synthesis of R-enantiomer of diol were received under precisely defined conditions, and as a results of scaling study conducted in automatic bath reactor (Table 2.). This is pioneer result, since in the previous studies, fresh mycelium of Aspergillus niger allowed receiving this product as (S) enantiomer. Also the use of Rhizopus arrhizus DSM 1185 (immobilized in polyurethane foams), gave important results, since the bioconversion of phenyl ethanol led, indeed to the racemic mixture of 1-phenylethane-1,2-diol, but it was accompanied by the noticeable tyrosol synthesis, what is reported for the first time.
Source: Symmetry
DOI: 10.3390/sym17010017
Institution: Wrocław University of Science and Technology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,728
Funder: Politechnika Wrocławska
Award: G5567444275
OpenAlex ID: W4405817994