Work

Identification of TIG1 Associated Molecular Targets for Breast Cancer Using Bioinformatic Approach

Year: 2024

Type: article

Abstract: e-posta/e-mail: [email protected]/[email protected] Kabul Tarihi/Accepted: Tazarotene-induced gene 1 (TIG1) is involved in modulating the α-tubulin modification and effectively inhibiting tumor growth. In this bioinformatics study, we aim to propose novel therapeutic targets in breast cancer by utilizing differentially expressed genes (DEGs) of TIG1 in inflammatory breast cancer (IBC) and examining their correlation with the molecular and immune subtypes. Using the GEO2R tool, we analyzed DEGs in the GSE30543 dataset, specifically comparing suppressed TIG1 groups with control samples from SUM149 cells. Functional annotation analysis of DEGs were explored using SRplot with data from STRING (|log2(FC)| >2 and p

Source: Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi

DOI: 10.37989/gumussagbil.1459020

Authors: Tuğcan Korak, Merve Gulsen Bal Albayrak, Gürler Akpınar, Murat Kasap

Institution: Kocaeli Üniversitesi

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405823375

FWCI:

Cites: 30

Cited by:

Related to: 10