Work

Syntaxin 4-enhanced plasma membrane repair is independent of dysferlin in skeletal muscle

Year: 2024

Type: article

Abstract: Dysferlin, a crucial Ca 2+ -binding protein in plasma membrane repair (PMR), shares homology with synaptotagmin, which binds Ca 2+ and regulates SNARE-mediated vesicle fusion in neurons. Dysferlin was thus hypothesized to function as synaptotagmin in PMR. We demonstrate here that the activity of SNAREs is important for PMR, and overexpression of STX4 enhances PMR in both intact and dysferlin-deficient skeletal muscle. These data suggest that SNARE-mediated PMR may be independent of dysferlin in skeletal muscle.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00507.2024

Authors: Hsin-Yu Chen, Daniel E. Michele

Institution: University of Michigan

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: University of Michigan, National Institutes of Health, Horace H. Rackham School of Graduate Studies, University of Michigan, National Institute of Arthritis and Musculoskeletal and Skin Diseases