Work

A new hydrated crystalline form of N -[( E )-(4-hydroxyphenyl)methylidene]-1 H -1,2,4-triazol-3-amine and its antifungal activity

Year: 2024

Type: article

Abstract: The synthesis, crystal structure, Hirshfeld analysis, and antifungal assessment of a new monohydrated Schiff base with a triazole moiety are reported. The structural study revealed the presence of three significant hydrogen bonds (N—H...N, O—H...N, and O—H...O), which contribute to the cohesion of the crystal. These bonds generate two-dimensional layers parallel to the bc plane, built on the basis of rings with the graph-set motifs R 4 4 (8) and R 4 4 (24). The crystal structure is further consolidated by π–π interactions between similar rings. The antifungal activity of the Schiff base was evaluated against three fungi: Fusarium oxysporum , Botrytis cinerea , and Alternaria alternata , showing significant antifungal activity, particularly against Alternaria alternata .

Source: Acta Crystallographica Section E Crystallographic Communications

DOI: 10.1107/s205698902401209x

Authors: Boualia Boutheina, Bouhidel Zakaria, Aouatef Cherouana, Bendeif El-Eulmi

Institutions: University Frères Mentouri Constantine 1, Synchrotron SOLEIL, Laboratoire de Cristallographie, Résonance Magnétique et Modélisations

Language: English

Topic: Crystal structures of chemical compounds

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $500

OpenAlex ID: W4405825145