Work

Investigation of dynamic behavior of human skin tissue under micro-particle impact in the context of transdermal drug delivery: numerical and analytical perspectives

Year: 2024

Type: article

Abstract: The understanding of the impact of high-velocity microparticles on human skin tissue is important for the administration of drugs during transdermal drug delivery. This paper aims to numerically investigate the dynamic behavior of human skin tissue under micro-particle impact in transdermal drug delivery. The numerical model was developed based on a coupled smoothed particle hydrodynamics (SPH) and FEM method via commercial FE software RADIOSS. Analytical analysis was conducted applying the Poncelet model and was used as validation data. A hyperelastic one-term Ogden model with one pair of material parameters ( µ, α ) was implemented for the skin tissue. Sensitivity studies reveal that the effect of parameter α on the penetration process is much more significant than µ . Numerical results correlate well with the analytical curves with various particle diameters and impact velocities, its capability of predicting the penetration process of micro-particle impacts into skin tissues. This work can be further investigated to guide the design of transdermal drug delivery equipment.

Source: Theoretical and Applied Mechanics Letters

DOI: 10.1016/j.taml.2024.100567

Authors: Jianbo Shen, Jiacai Huang, Yaoke Wen, Sebastien Roth

Institutions: Nanjing Institute of Technology, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing University of Science and Technology, Centre National de la Recherche Scientifique, Université de technologie de belfort-montbéliard

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,200