Work

The claudin family of proteins in the pathogenesis and treatment of malignancies: current insights and future prospects

Year: 2024

Type: article

Abstract: This review presents data concerning claudins, the proteins of tight junctions, and their role in the pathogenesis and therapy of malignancies. Particular attention is paid to the variability in claudin expression levels, their intracellular localization in tumors, and the prognostic significance of these variations in cancer. The review highlights the role of claudins in metastatic spread, invasion, and tumor cell resistance to antitumor drug therapy. Moreover, the potential of claudins as targets for novel diagnostic and treatment methods for malignant neoplasms is also discussed.

Source: Russian Journal of Oncology

DOI: 10.17816/onco636917

Authors: Sergei V. Boichuk, Firyuza F. Bikinieva, Pavel B. Kopnin

Institutions: Kazan State Medical University, Kazan Federal University, Russian Medical Academy of Continuous Professional Education, Russian Cancer Research Center NN Blokhin

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405833076

FWCI: 0.268

Cites: 147

Cited by: 2

Related to: 10