Work

Antimicrobial Resistance Patterns of Clinically Isolated Strains of Acinetobacter baumannii in a Tertiary Care Hospital in Libya

Year: 2024

Type: article

Abstract: Objective: Acinetobacter baumannii accounts for a notable percentage of hospital-acquired infections. The widespread resistance to multiple antibiotic classes complicates treatment efforts. This study aims to find out the pattern of susceptibility of multidrug-resistant A. baumannii (MDRAB) isolated from clinical specimens to antibiotics recommended for testing and use for A. baumannii and to determine a local guide at Tripoli University Hospital (TUH), Tripoli, Libya for the empirical antibiotic treatment of MDRAB based on the susceptibility pattern identified. Materials and methods: This retrospective cross-sectional study was carried out in the Department of Microbiology at TUH in Libya from January 2021 to June 2021. Identification of isolates was performed using the VITEK® 2 automated system (bioMérieux, France), and the isolates were categorized as susceptible, intermediate susceptible, or resistant according to the minimum inhibitory concentration (MIC). Results: A total of 86 A. baumannii isolates were obtained from various clinical specimens from different departments. Isolates show high resistance to most of the tested antibiotics. Beta-lactams and ciprofloxacin were found to be the most resistant, while the highest susceptibility was detected to minocycline and amikacin. Conclusion: These findings prompt clinicians to consider taking minocycline and amikacin into account when starting empirical therapy for severe infections caused by A. baumannii.

Source: Cureus

DOI: 10.7759/cureus.76483