Effect of Centratherum anthelminticum seeds on Glycated hemoglobin, Cardiovascular disease risks and dyslipidemia in Type-2 diabetic patients in Karachi: A non-blind randomized controlled trial
Year: 2024
Type: article
Study design: Clinical Trial
Abstract: Objective: To explore the effect of Centratherum antheminticum seeds powder {CapCASP 500 mg} capsule in diabetes Type-2 (T2DM) patients in Karachi. Methods: A randomized selection of 40 T2DM patients from Sindh Government Hospital New Karachi with their consents was done for a non-blinded controlled trial from October to December 2019 and divided into PGroup (Positive Control, metformin 500 mg) & TGroup (Test, CapCASP + was also included, using the same dosage of CapCASP on twenty healthy volunteers. The data were analyzed using an online graph pad student’s t-test and a one-way ANOVA (SPSS version 24) metformin 500mg each). Both groups had (n = 20). CGroup (healthy control), was also included with twenty healthy volunteers with same dose of CapCASP. The biochemical tests (lipid profile, HbA1c, fasting blood glucose) of both groups were done in biochemistry lab Federal Urdu University of Arts, Science & Technology and results were analyzed by one-way ANOVA (SPSS version 24) and online graph pad student´s t-test. Results: CASP showed potent (in-vitro) anti-diabetic activity (72.81%) than standard acarbose (standard drug). Most of in-vivo parameters in TGroup showed significant improvements. Body weight (p<0.01) & (p<0.05), HbA1c & fasting blood glucose (p<0.0001), coronary risk index (CRI), atherogenic index (A Indx) (p<0.05, p<0.0001) & atherogenic dyslipidemia ratio (A-DLR) (p<0.0001 & p<0.01) were reduced after six and twelve weeks. Reduction in serum cholesterol and triglycerides (p< 0.05 & p< 0.01) after six as well as (p< 0.01) after twelve weeks. Very low density lipoprotein reduced after both (p< 0.05) six and (p< 0.0001) twelve weeks. High density lipoprotein increased (p< 0.01) & low density lipoprotein decreased (p< 0.05) after twelve weeks. Conclusion: When given standard care to T2D patients, the CASP intervention demonstrated both anti-diabetic and anti-lipidemic effects. doi: https://doi.org/10.12669/pjms.41.1.8496 How to cite this: Mudassir HA, Arshad SMT, Naheed M, Anwer S. Effect of Centratherum anthelminticum seeds on Glycated hemoglobin, Cardiovascular disease risks and dyslipidemia in Type-2 diabetic patients in Karachi: A non-blind randomized controlled trial. Pak J Med Sci. 2025;41(1):257-262. doi: https://doi.org/10.12669/pjms.41.1.8496 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institution: Federal Urdu University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $400
OpenAlex ID: W4405840698