Year: 2024
Type: article
Abstract: Long-term control of viral replication relies on the efficient differentiation of memory T cells into effector T cells during secondary immune responses. Recent findings have identified T cell precursors for both memory and exhausted T cells, suggesting the existence of progenitor-like effector T cells. These cells can persist without antigenic challenge but expand and acquire effector functions upon recall immune responses. In this study, we demonstrate that the combination of SLAMF7 with either CD27 or TCF-1 effectively identifies progenitor-like effector CD8 T cells, while SLAMF7 with GPR56 or TOX defines effector CD8 T cells. These markers allow for the clear segregation of these distinct cell subsets. SLAMF7 + CD8T cells are dynamically modulated during viral infections, including HIV, HCV, CMV, and SARS-CoV-2, as well as during aging. We further characterize the SLAMF7 signature at both phenotypic and transcriptional levels. Notably, during aging, the SLAMF7 pathway becomes dysregulated, resulting in persistent phosphorylation of STAT1. Additionally, SLAMF7 ligation in the presence of IL-15 induces TCF-1 expression, which promotes the homeostatic proliferation of progenitor-like effector CD8 T cells.
Source: Scientific Reports
Authors: Hassen Kared, Crystal Tan, Vipin Narang, Shu Wen Tan, Chin Hui Xian, Alicia Tay Seok Wei, Josephine Lum, Ezequiel Ruiz-Mateos, Reena Rajasuriar, Adeeba Kamarulzaman, Tze Pin Ng, Anis Larbi
Institutions: Agency for Science, Technology and Research, Oslo University Hospital, University of Oslo, Singapore Immunology Network, Consejo Superior de Investigaciones Científicas, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, The University of Melbourne, University of Malaya, Peter Doherty Institute, National University of Singapore
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,590
Funders: International Society for Advancement of Cytometry, Agency for Science, Technology and Research, Ministry of Higher Education, Malaysia, Ministerio de Economía y Competitividad, Universiti Malaya, Consejo Superior de Investigaciones Científicas, Instituto de Salud Carlos III, Biomedical Research Council
Awards: G1075404386, G1561614896, G1829889632, G1839124119, G1897439587, G1926213114, Papel de las células plasmacitoides dendríticas en el control espontáneo de la replicación del VIH y en su patogénesis. Relevancia clínica de los mecanismos implicados., G4198687110, Análisis del perfil metabólico asociado con la progresión y con el control espontáneo de la infección por VIH. Papel de las pDCs en la reducción del tamaño del reservorio celular latente., G4722202795, G4821362207, G5953849721, G6819369096, G7180200661, G7742180697, G8029093941, G921967825
OpenAlex ID: W4405842554