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Oxidative Monofluorination of 1,4-Diiodo(or Dibromo)-2,3,5,6-tetramethylbenzenes in the System PbO₂—HF—Py—CH₂Cl₂

Year: 2024

Type: article

Abstract: The oxidation of 1,4-diiodo-2,3,5,6-tetramethylbenzene (diiododurene) and 1,4-dibromo-2,3,5,6-tetramethylbenzene (dibromodurene) by lead dioxide PbO₂ in Olah reagent, hydrogen fluoride-pyridine mixture, with CH₂Cl₂ as a co-solvent at room temperature for 96 h results in the corresponding products of monofluorination of methyl group. This is the first example of using the oxidative system PbO₂—HF—Py—CH₂Cl₂ for side-chain monofluorination of methylated benzenes.

Source: Журнал органической химии

DOI: 10.31857/s0514749224020011

Authors: M. V. Kalyaev, D. S. Ryabukhin, A. V. Vasilyev

Institutions: St Petersburg University, Saint Petersburg State Forest Technical University, All-Russian Research Institute of Food Additives

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W4405844695

FWCI:

Cites: 27

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Related to: 10