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IgG4-Related Lymphadenopathy Mimicking Mediastinal Lymph Node Metastasis of Lung Cancer on 18F-FDG PET/CT

Year: 2024

Type: article

Abstract: F-FDG PET/CT for suspected disease progression. Imaging showed increased FDG uptake in the right lower lung mass and systemic lymphadenopathy (mediastinal, supraclavicular, axillary, paraaortic, and iliac regions). The appearance of a stable lymph node and a clinical history of IgG4 lymphadenopathy suggested an inflammatory process, although malignancy in the lung mass and mediastinal nodes could not be excluded. Lobectomy confirmed the presence of lung adenocarcinoma, while radical lymph node dissection identified IgG4-related lymphadenopathy without metastasis. This case underscores the need for considering differential diagnosis of PET-positive lymphadenopathy, especially in patients with comorbid conditions that mimic or coexist with malignancy.

Source: Diagnostics

DOI: 10.3390/diagnostics15010041

Authors: Ting-Chun Tseng, Hung-Pin Chan, Daniel Hueng-Yuan Shen, Chang-Chung Lin

Institutions: Kaohsiung Veterans General Hospital, National Sun Yat-sen University

Language: English