Spinning, Sliding, Flexing, and Jumping of Theophylline Sulfate between Concomitant Polymorphs and Hydrates
Year: 2024
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide The solid form screening of theophylline (TP) and sulfuric acid led to a collection of new crystals including two anhydrous sulfate salts (TPH + HSO 4 – form I and TPH + HSO 4 – form II) and two hydrated salts (bis-theophyllinium sulfate monohydrate ([TPH + ] 2 SO 4 2– ·H 2 O) and theophyllinium hydrogen sulfate dihydrate (TPH + HSO 4 – ·2H 2 O)). The new structures were determined and their stability was investigated, suggesting multiple modes of movement for the ions in the solid state. Anhydrous TPH + HSO 4 – form II exhibits unusually large anisotropic linear thermal expansion, associated with the elongation of a unique sulfate−π contact. Additionally, thermal dehydration of TPH + HSO 4 – ·2H 2 O occurs in a salient, rocketlike manner that may be caused by the sudden release of water vapor trapped inside the particles.
Source: Crystal Growth & Design
Authors: Enrico Spoletti, Ricardo Albarran Velo, Cathal Phelan, Cian Williams, Matteo Lusi
Institutions: University of Bern, University of Limerick
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W4405850932