Work

The value of semiquantitative analysis of [ 99m Tc]MDP SPECT/CT in localizing responsible lesions for suspected fresh osteoporotic vertebral compression fractures in patients with contraindications to MRI

Year: 2024

Type: article

Abstract: PURPOSE: The aim of this study was to evaluate the effectiveness of single-photon emission computed tomography/computed tomography (SPECT/CT) in detecting and localizing the causative vertebra in cases of suspected fresh osteoporotic vertebral compression fractures (OVCFs) in patients with contraindications to MRI. METHODS: Tc]MDP SPECT/CT before percutaneous vertebroplasty (PVP). Clinical outcomes and radiographic parameters, including basic demographics, injury duration, focal kyphosis (FK), loss of vertebral height (LVH), and relative intensity values (RIVs) for target and nontarget segments in the SPECT/CT were measured. RESULTS: SPECT/CT identified 14 old and 26 fresh OVCFs. Of these, 18 patients with 26 fresh OVCF segments underwent PVP, and achieved satisfactory outcomes. Significant differences were observed in the RIV, FK, and LVH values between the fresh and old OCVF groups (all p < 0.05). RIVs showed a significant negative correlation with injury duration (r = -0.57, p < 0.05), and a positive correlation with LVH (r = 0.43, p < 0.05). Multiple linear regression analysis confirmed that injury duration was an independent predictor of RIVs (p < 0.05). CONCLUSION: SPECT/CT is useful for detecting and differentiating fresh fractures from old fractures in patients having OVCF who cannot undergo MRI after BPIT validation, allowing these patients to achieve excellent clinical outcomes following PVP. The RIV serves as a valuable parameter for assessing the duration of fresh versus old OVCFs. TRIAL REGISTRATION: ChiCTR, ChiCTR 2300077570. Retrospectively registered, http://www.chictr.org.cn/showproj.html?proj=206192.

Source: Clinical Physiology and Functional Imaging

DOI: 10.1111/cpf.12923

Authors: Sheng Shi, Hai‐Dong Cai, Gai‐Xia Lu, Li‐Guo Zhang, Shuang Zheng, Shi‐Sheng He

Institutions: Tongji University, Shanghai Tenth People's Hospital, Shanghai University

Language: English

Topic: Spinal Fractures and Fixation Techniques

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Natural Science Foundation of China, Science and Technology Commission of Shanghai Municipality, Science and Technology Innovation Plan Of Shanghai Science and Technology Commission