Work

Cs2CO3‐I2 Promoted Efficient Synthesis of Flavones and Flavanones: Total Synthesis of Narengenin and Apigenin

Year: 2024

Type: article

Abstract: Flavonoids are an important class of naturally existing scaffolds known for their diverse biological activities and have been immensely synthesized using stoichiometric reagent amounts. Herein, we report a reliable, robust, one‐pot, transition metal and additive‐free protocol for the synthesis of flavones and flavanones from 2‐hydroxyacetophenone and substituted aldehydes. Our developed method utilizes Cs2CO3 as a base and iodine as an oxidant in H2O: DMSO (9 : 1) solvent system, which provides direct access to many flavones and flavanones in excellent yields under milder reaction conditions with simple yet easily available substrates. In application, naturally occurring compounds such as naringenin and apigenin have been successfully synthesized using developed protocol.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202401298

Authors: Kailas Arjun Chavan, Rohan D. Erande

Institution: Indian Institute of Technology Jodhpur

Language: English

Topic: Synthesis of Organic Compounds

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze