Work

Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs

Year: 2024

Type: article

Abstract: Targeting is the most challenging problem to solve for drug delivery systems. Despite the use of targeting units such as antibody, peptides and proteins to increase their penetration in tumors the amount of therapeutics that reach the target is very small, even with the use of nanoparticles. Nature has solved the selectivity problem using a combination of proteins and lipids that are exposed on the cell membranes and are able to recognize specific tissues as demonstrated by cancer methastasis. Extracellular vesicles, EVs have a similar ability in target only certain organs or to go back to the original cells, homing behavior. Here we report a strategy inspired by nature, using a combination of nanoparticles and the targeting cell membranes of extracellular vesicles, EVs. We implement the EV membranes, extracted by the EVs produced by melanoma B16-BL6 cells, as a coating of organosilica porous particles with the aim of targeting tumors and lung metastasis, while avoiding systemic effects and accumulation of the nanoparticles in undesired organs. The tissue-specific fingerprint provided by the EVs-derived membranes from melanoma cells provides preferential uptake into the tumor and selective targeting of lungs. The ability of the EVs hybrid systems to behave as the natural EVs was demonstrated in vitro and in vivo in two different tumor models. As a proof of concept, the loading and release of doxorubicin drug, was investigated and demonstrate its accumulation in the expected tissues.

Source: Materials Today Bio

DOI: 10.1016/j.mtbio.2024.101433