Work

Biologics to the Rescue in Case of Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis

Year: 2024

Type: article

Abstract: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious adverse drug reactions, triggered by medications, infections, malignancies and idiopathic causes. Clinically, they manifest as widespread, painful erythematous macules and target-like lesions, often accompanied by full-thickness or localised epidermal necrosis. Our patient, a 33-year-old male, presented with oral ulcers and painful red lesions starting from the face and progressing to involve trunk and upper extremities 5 days after administration of intravenous diclofenac for severe headache. Additional symptoms included ulceration over lips and buccal mucosa. He was diagnosed clinically as a case of SJS-TEN overlap with Severity of illness score for toxic epidermal necrolysis (SCORTEN) of 3 and was given intravenous corticosteroids. Here, we report a case of SJS-TEN overlap with corticosteroids-induced acute psychosis, treated successfully with etanercept monotherapy.

Source: Indian Journal of Postgraduate Dermatology

DOI: 10.25259/ijpgd_200_2024

Authors: Sharmila Patil, Manjyot Gautam, Fiza Mohd Rafiq Choudhary, Anmol Vivek Israni, Akanksha Keshav Ghodke

Institution: D.Y. Patil University

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4405855945

FWCI:

Cites: 8

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Related to: 10