Work

Efficient Method for Obtaining a Precursor in Non-stereospecific Synthesis of Mianserin and Epinastine

Year: 2024

Type: article

Abstract: A new method for obtaining one of the precursors in the non-stereospecific synthesis of the drugs mianserin and epinastine, namely, (S,R)-6-(phthalimidomethyl)-6,11-dihydro-5H-dibenzo[b,e]azepine is described, which consists in the cyclization of the intermediate amide in a polyphosphate ester medium (ethyl polyphosphate, PPE).

Source: INEOS OPEN

DOI: 10.32931/io2443a

Author: A. V. Toktonov

Institutions: Russian Academy of Sciences, A. N. Nesmeyanov Institute of Organoelement Compounds

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: Ministry of Science and Higher Education of the Russian Federation, Lomonosov Moscow State University

Award: G2231888424