Work

7α-Fluorooxycodone

Year: 2024

Type: article

Abstract: A C(7)-fluorinated derivative of oxycodone was obtained for the first time by the electrophilic fluorination of the lithium enolate of oxycodone. The reaction involving Selectfluor proceeds stereoselectively and results in the formation of a single C(7)-epimer. The structure of the newly prepared 7α-fluorooxycodone was confirmed by X-ray diffraction.

Source: INEOS OPEN

DOI: 10.32931/io2454a

Authors: I. V. Sandulenko, M. B. Zelentsova, A. F. Smol'yakov, A. A. Ambarsumyan, S. K. Moiseev

Institutions: Russian Academy of Sciences, A. N. Nesmeyanov Institute of Organoelement Compounds

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: hybrid

Funder: Ministry of Science and Higher Education of the Russian Federation

Award: G2231888424